This past Sunday, CBS’ 60 Minutes aired a segment on antidepressants being no better than placebo. Harvard researcher and author Irving Kirsch says antidepressants do not work because of the ingredients inside them or any effect they have on serotonin, but because we believe we’ll get better when we take them. We could just as easily be taking a sugar pill, without knowing it, and we’d get the same effect, he argues.
If you saw the story, you might be feeling very confused right now. Even Lesley Stahl, who reported the story and whose husband takes an antidepressant, said she was confused. Kirsch and others interviewed were very confident that SSRIs don’t have the impact that pharmaceutical companies would have us believe.
I take one. It seems like it works for me. Yet does it really? Am I just fooled into believing it works?
John Grohol, editor-in-chief of Psych Central, responded, “What wasn’t mentioned in the 60 Minutes piece, because it was opinion journalism forwarding a specific viewpoint, is that Kirsch’s research is selective. He hasn’t looked at every antidepressant study ever done (now numbering in the thousands). He only looked at the clinical trials required to gain U.S. Food and Drug Administration approval for 6 antidepressant drugs (there are over a dozen on the market).”
I reached out for input from Dr. Marlene Freeman of the Massachusetts General Hospital Center for Women’s Mental Health for input as it applies to women with postpartum depression — well, everyone really, but my focus is women with postpartum depression — and I want you to see her response. It really helped me to understand the placebo effect better and why people like Hirsch make the claims they make: [Read more...]














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